Professor Alexander V. Zholos, BSc, PhD, DSc, FPhysiol

Head of the Department of Biophysics and Medical Informatics

Educational and Scientific Centre “Institute of Biology and Medicine” of Taras Shevchenko National University of Kyiv

Learned Secretary of the Ukrainian Biophysical Society

Fellow of The Physiological Society (UK)

 

After graduation from the Department of Biophysics (in 1981, headed at that time by Prof. V.L. Zyma), T.G. Shevchenko Kiev State University, Alex Zholos entered smooth muscle research through PhD study with the world-known in this area Prof. Michael Shuba at the famous Bogomoletz Institute of Physiology in Kyiv, Ukraine. This was at the very beginning of what will soon to become a very proliferative era of ion channel research with the use of the patch-clamp techniques. In this period, he pioneered studies of the mechanisms of calcium-induced calcium release in visceral smooth muscles.

His first postdoctoral position was in the laboratory of Prof. Jackie Wood at The Ohio State University (Columbus, USA), who is world-known for his studies of the enteric nervous system - the "minibrain-in-the-gut". His first patch-clamp recordings of several different ion channel currents in myenteric neurones have been later published with Jack Wood in 4 papers.

He then went on to continue smooth muscle research by joining the famous group of scientists at St. Georges Hospital Medical School in London, headed by Prof. Thomas Bolton and known as “Smoothies”. Much of their work focused on various aspects of the muscarinic cation current, which they termed mIcat. This research was published in 24 papers.

He later became an independent scientist as Head of Laboratory of Molecular Pharmacology of Cellular Receptors and Ion Channels at the Bogomoletz Institute of Physiology, then Director of Research of the newly created Cardiovascular Biomedical Research Centre, School of Medicine and Dentistry, Queen's University Belfast, UK. He has earned his Professorial titles in several disciplines and in 3 countries: Professeur des universités (Physiology) (Ministry of Education, Higher Education and Research, France, 2005), Chair in Vascular Physiology/Vascular Biology (Queen's University Belfast, UK, 2005), and Professor in Biophysics (Ministry of Education and Science of Ukraine, 2014). A.V. Zholos is a member of Editorial Boards of "International Journal of Physiology and Pathophysiology " (Ukraine), as well as several international journals - Frontiers in Pharmacology (Review Editor of Frontiers in Integrative and Regenerative Pharmacology), ISRN Physiology, European Biophysics Journal.

He now leads the Department of Biophysics and Medical Informatics at the ESC "Institute of Biology and Medicine". Always being fond of Biophysics as one of the most exact biological disciplines, he at the same time feels very honored to recently become a Fellow of The Physiological Society (UK) in recognition of his continuous and active service to The Society and to this discipline.

His current research focuses on TRP channels, including single-channel mechanisms, and on the development of novel activators of maxi-K channels, which can be useful for the treatment of many disease states associated with hyperactivity of smooth muscles (e.g. hypertension, bronchial asthma, IBS): ORCID.

He currently teaches 3 general courses at both BSc and MSc levels (“Biophysics”, “Modern Informational Technologies in Biology”, “Bioinformatics”), as well as a number of specialized courses, including “Electrobiophysics”, “Basis of Modern Pharmacology” (in English), “Electrogenesis in Living Systems”, “Molecular and System Mechanisms of Drug Action”. With his departmental colleagues he is currently introducing a new MSc specialization “Biophysics and Medical Informatics”, as well as two new courses for medics - “Medical Informatics” and “Medical and Biological Physics”.

As one of his hobbies, he is happy to help his fellow patch-clampers by developing Origin scripts for automating both common and advanced types of patch-clamp data analysis.